Table 1. SAM results, genes deregulated in Responders (R) group.
Probe ID | Gene Symbol | Expression | meanNR | mean R | Description |
---|---|---|---|---|---|
GC10P005126_at | AKR1C3Gene ID: 8644 | ↓R | 8.818 | 7.766 | Encodes a member of the aldo/keto reductase superfamily. It catalyzes the conversion of aldehydes and ketones to alcohols. |
GC04M077145_at | CXCL11 Gene ID: 6373 | ↑R | 3.787 | 4.875 | Is a CXC member of the chemokine superfamily. Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes, ligand for the receptor CXCR3. |
GC04M077132_at | CXCL10 Gene ID: 3627 | ↑R | 6.693 | 7.680 | Encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. |
GC08P039891_at | IDO1Gene ID: 3620 | ↑R | 6.095 | 7.007 | Encodes a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine, immune-modulatory properties. |
GC04M077112_at | CXCL9 Gene ID: 4283 | ↑R | 6.130 | 7.064 | The function has not been specifically defined; however, it is thought to be involved in T cell trafficking, ligand for the receptor CXCR3 |
GC11M102238_at | MMP12 Gene ID: 4321 | ↑R | 8.819 | 9.580 | Encodes a protein of the matrix metalloproteinase (MMP) involved in the breakdown of extracellular matrix. |
GC06P032434_at | HLA-DRA Gene ID: 3122 | ↑R | 7.759 | 8.430 | Encodes a protein that binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. |
Only genes with FDR < 1% and q-value = 0 are listed