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. 2015 Sep 2;6(32):32561–32574. doi: 10.18632/oncotarget.4935

Table 1. SAM results, genes deregulated in Responders (R) group.

Probe ID Gene Symbol Expression meanNR mean R Description
GC10P005126_at AKR1C3Gene ID: 8644 ↓R 8.818 7.766 Encodes a member of the aldo/keto reductase superfamily. It catalyzes the conversion of aldehydes and ketones to alcohols.
GC04M077145_at CXCL11 Gene ID: 6373 ↑R 3.787 4.875 Is a CXC member of the chemokine superfamily. Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes, ligand for the receptor CXCR3.
GC04M077132_at CXCL10 Gene ID: 3627 ↑R 6.693 7.680 Encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3.
GC08P039891_at IDO1Gene ID: 3620 ↑R 6.095 7.007 Encodes a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine, immune-modulatory properties.
GC04M077112_at CXCL9 Gene ID: 4283 ↑R 6.130 7.064 The function has not been specifically defined; however, it is thought to be involved in T cell trafficking, ligand for the receptor CXCR3
GC11M102238_at MMP12 Gene ID: 4321 ↑R 8.819 9.580 Encodes a protein of the matrix metalloproteinase (MMP) involved in the breakdown of extracellular matrix.
GC06P032434_at HLA-DRA Gene ID: 3122 ↑R 7.759 8.430 Encodes a protein that binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells.

Only genes with FDR < 1% and q-value = 0 are listed