Table 2. Molecular Twins*.
| Complete Molecular Profile | Histology 1 | Histology 2 | Histology 3 |
|---|---|---|---|
| IDH1 R132H | Oligodendroglioma | Oligodendroglioma | Glioblastoma |
| KRAS G12D and GNAS R201C | Lung adenocarcinoma | Appendiceal carcinoma | — |
| CDK4 and MDM2 amplification | Liposarcoma | Lung adenocarcinoma | — |
*
Only the patients shown above had identical molecular profiles (molecular twins). IDH1 R132H was found in three primary CNS tumors. KRAS G12D with GNAS R201C was found in one patient with lung adenocarcinoma as well as in a patient with appendiceal carcinoma. CDK4 amplification and MDM2 amplification were found in liposarcoma and lung adenocarcinoma.