Figure 3. Effect of oncogenic stimulation by platelet-derived growth factor B (PDGF-B) on proliferation of arachnoidal cells in culture alone or in combination with Nf2 inactivation.

A. Morphology of arachnoid cells in culture. B. Hemagglutinin A (HA)-immunocytochemistry in arachnoid cells in vitro. C. Effect of PDGF-B overexpression on the growth of arachnoid cells in vitro, alone (left) or in combination with Nf2 bi-allelic inactivation (right) D. Western blot analysis of arachnoid cells demonstrating increased PDGFR immunoreactivity in arachnoidal cells infected with RCAS-PDGF-B compared to controls.