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. 2015 Sep 24;6(32):32713–32722. doi: 10.18632/oncotarget.5296

Figure 4. Role of PDGF-B alone or in association with Nf2 loss and Cdkn2ab loss in meningiomagenesis.

Figure 4

A. Survival curves of PGDStv-a;RCAS-PDGF-B mice (n = 26), AdCre;Nf2flox2/flox2 mice (n = 25), PGDStv-a het; RCAS-PDGF-B; AdCre;Nf2flox2/flox2 mice (n = 29), AdCre;Nf2flox2/flox2; Cdkn2ab−/− mice (n = 53) and PGDStv-a;RCAS-PDGF-B;AdCre;Nf2flox2/flox2;Cdkn2ab−/− (n = 19) mice after perinatal injection. B. Proportion of meningioma histological grades in the different mice cohorts : 1. PGDStv-a;RCAS-PDGF-B mice, 2. AdCre;Nf2flox2/flox2 mice, 3. PGDStv-a;RCAS-PDGF-B;AdCre;Nf2flox2/flox2 mice, 4. AdCre;Nf2flox2/flox2;Cdkn2ab−/− mice, 5. PGDStv-a;RCAS-PDGF-B;AdCre;Nf2flox2/flox2;Cdkn2ab−/− mice.