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. 2015 Jul 22;6(32):32748–32760. doi: 10.18632/oncotarget.4977

Figure 5. Effect of a chemical GLUT1 inhibition on human melanoma cells in vitro.

Figure 5

The human melanoma cell line WM3211 was treated with the chemical GLUT1 inhibitor WZB117 at the concentrations indicated. A. Proliferation analyzed with XCELLigence™ system, B. XTT activity and C. proportion of apoptotic cells (Annexin V-FITC FACS analysis). Migratory activity analyzed with D. Boyden chamber and E. time-lapse scratch assays (bar depicts the original width of the scratch), and F. MMP2 mRNA expression levels. G. Western blot analysis of phosphorylated JNK1/2 (Thr183/Tyr185) and c-JUN (Ser73). (*p < 0.05 compared to control).