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. 2015 Sep 25;6(32):32890–32901. doi: 10.18632/oncotarget.5335

Figure 1. LYAR is highly expressed in human metastatic CRC tissues.

Figure 1

A. Immunohistochemical staining of the LYAR protein in adjacent normal and carcinoma tissues from colorectal cancer patients. Representative micrographs are shown at the original magnification (50 × and 200 × ) as indicated. Low (−, +) and high LYAR expression (++, +++) were classified according to the LYAR immunostaining scores, IRS. B. The percentage of patients with different metastasis statuses (M0, no regional or distant metastasis; M1, regional or distant metastasis) and differentiation grades as scored by IRS. *P < 0.05 compared with the indicated group. C. Western blot analysis of LYAR in cell lysates from normal adjacent tissues (NAT) and colorectal tumor tissues (CRC) (n = 15). GAPDH served as a loading control. D. Quantitation of the density of the protein bands from the western blots in (C); P < 0.01 compared with the paired NAT. E. Quantitation of the LYAR mRNA levels normalized to GAPDH mRNA levels from the tissues from in (C). *P < 0.05 compared with the NAT control.