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. 2015 Oct 12;6(32):32980–33005. doi: 10.18632/oncotarget.5431

Figure 14. K14-Cdx2::L2-IL-1β transgenic mice have reduced expression of key regulators of immature myeloid cell inducers IL-17 and S100A8/a9.

Figure 14

A. Relative IL-17A, IL-17C and S100A9 expression from esophageal and SCJ metaplasia tissues of L2-IL-1β and K14-Cdx2::L2-IL-1β mice. n = 3 mice in each group. Error bars display standard deviations; p values based on one-sided student T-testing comparing gene expression in L2-IL-1β and K14-Cdx2::L2-IL-1β mice; ‡ p = 0.164; *p = 0.049; **p = 0.036; ***p ≤ 0.018; n = 3 animals for each genotype, with each sample assayed in triplicate. B. Immunostaining for S100A9 in esophagi of L2-IL-1β and K14-Cdx2::L2-IL-1β mice. E; squamous epithelium; SM: submucosa. n = 3 mice in each group. C. Model for the onset of metaplasia in L2-IL-1β mice, and its inhibition in K14-Cdx2::L2-IL-1β mice. IMC: immature myeloid cells; Green arrows-enhancing activity, red lines-inhibitory function.