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. 2015 Oct 12;6(32):32980–33005. doi: 10.18632/oncotarget.5431

Figure 7. Cdx2 overexpression in L2-IL-1β transgenic mice leads to downregulated myeloid cell genes in the SCJ metaplastic nodules but no effect on CD45+ cell infiltration.

Figure 7

An Affymetrix microarray analysis of gene expression in the SCJ nodules from K14-Cdx2::L2-IL-1β mice and L2-IL-1β mice was performed. A. Green box: A partial list of the gene function annotation using DAVID bioinformatic resources of the 47 genes whose expression is increased in K14-Cdx2::L2-IL-1β mice with a p < 0.05. B. Red Box: A partial list of the gene ontogeny analysis of the 152 genes diminished in K14-Cdx2::L2-IL-1β mice compared to L2-IL-1β mice with a p < 0.05. Green shading highlights immune or inflammation associated processes. C–E. Immunohistochemistry for CD45+ cells at the SCJ from 12-month DCA treated mice. (C) Non-transgenic WT mice, (D) L2-IL-1β mice, and (E) K14-Cdx2::L2-IL-1β mice (X200 magnification, red bar = 50 μm).