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. 2015 Sep 7;6(32):33178–33190. doi: 10.18632/oncotarget.5090

Figure 5. Pentose phosphate pathway (PPP).

Figure 5

The PPP mainly produces NADPH and pentoses. As a rate-limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD) performs the oxidation of glucose-6-phosphate, the first reaction of the PPP. A. A schematic diagram of the PPP. Levels of the metabolites found in this pathway are shown in B. G6PD: glucose-6-phosphate dehydrogenase. P values were calculated via 2-way ANOVA contrasts test. * < 0.05; ** < 0.01; p values between 0.05 and 0.1 are shown as numbers. Y-axis: relative amount of metabolite. Legends descriptions are the same as in Figure 2C. Metabolites showing significant changes are highlighted in red.