Table 1. Statistical summary of significant alterations of the metabolites.

ANOVA Contrasts	Starved/Control		p73 KO/WT
	WT	p73 KO	Control	Starved
Total biochemicals p ≤ 0.05	118	131	42	37
Biochemicals (increased/decreased)	68|50	58|73	31|11	18|19
Total biochemicals 0.05 < p < 0.10	38	34	25	38
Biochemicals (increased/decreased)	25|13	20|14	14|11	14|24
Two-Way ANOVA	Genotype Main Effect	Treatment Main Effect	Genotype:Treatment Interaction
Total biochemicals p ≤ 0.05	71	184	34
Total biochemicals 0.05 < p < 0.10	35	19	32

Contrasts resulting from 2-way ANOVA shown in the upper table were used to identify the metabolites that differed significantly between experimental groups. The lower table shows the numbers of significantly changed metabolites in consideration of genotype, treatment, and interaction.