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. 2015 Aug 12;6(32):33237–33252. doi: 10.18632/oncotarget.4893

Figure 1. The expression of TβRII and miR-20a are inversely correlated in lung cancer.

Figure 1

A. Total RNA was purified from human lung cancer cell lines A549, ACC-LC-176 (ACC) and VMRC-LCD (VMRC) and immortalized normal lung epithelial cell lines Beas2B and HPL1A. Expression of miRNAs was analyzed by microarray. B. MiR-20a levels in human lung cell lines A549, ACC, VMRC, Beas2B and HPL1A, and Beas2B and HPL1A cells with miR-20a stable expression (Beas2B-20a and HPL1A-20a as positive control) were analyzed by northern blotting. Small non-coding RNA U6 was used as loading control. C. RNA-seq based exon expression data for TΔRII and miR-20A were obtained from 488 lung adenocarcinoma patients and 490 lung squamous carcinoma patients and analyzed for association by Spearman-rank. A P-value of P < 0.05 was considered significant. The correlation coefficients (R) and associated P-values are shown. The scatter plot demonstrates the correlation between two continuous variables.