Table 2. Transcriptome changes in the downregulated mRNA expression of genes related to tumor immune responses and desmoplastic reaction upon combination treatment.

Gene	fold change	‘p’ value
IL-1β	13.26	<0.002
Mst1r	40.06	<0.02
TGFβr1	6.09	<0.02
TGFβr2	14.09	<0.03
Fibronectin 1	18.85	<0.03
PDGFβ	3.53	<0.02
PDGFrb	6.26	<0.05
VEGFa	1.61	<0.03
CSF-1	5.27	<0.002
SDF-2	3.24	<0.01
CD44	19.82	<0.05
IL-6ra	4.03	<0.02
PD1 (PDCD1)	6.80	<0.02
CD68	9.99	<0.047
CD163	7.26	<0.045