Skip to main content
. 2015 Sep 5;6(32):33397–33409. doi: 10.18632/oncotarget.5179

Figure 5. BRAF mutant melanoma cells are sensitive to JQ1 through other mechanisms.

Figure 5

A. Viability of BRAF-mutant cutaneous melanoma cells (SK-Mel19 and SK-Mel29) was assayed after 4 days of exposure to increasing doses of JQ1 treatments. B. Immunoblot analysis of BRAF-mutant cells treated with 500 nM JQ1 over time, using antibodies against c-Myc, Bcl-xL, Rad51, Brca1, Wee1 and PARP. C. The same genes were silenced and their expression was tested by immunoblotting. D. siRNA-transfected cells were tested for cell viability after 72 hours from transfection. Bars, mean ± sd