Figure 8. JQ1 inhibits UM tumor growth in vivo.

A. JQ1 inhibited tumor growth in a xenograft model with the Gnaq-mutant 92.1 cell line. Six- to eight-week SCID female mice were subcutaneously injected with 92.1 cells. Drug treatments began after tumors reached 100 mm³. Mice bearing tumors were treated daily with JQ1 (35 mg/kg) orally for 5 days each week for a total of 3 weeks. Tumors were measured with calipers every 2 to 3 days and tumor volumes were compared between groups of mice at various points in time. Each value represents the mean measurement of 5 animals, ± SEM, *P < 0.05. B. Xenograft tumors were collected at the end of treatments from two vehicle- and two JQ1-treated mice, and analyzed by Western blotting with antibodies for Bcl-xL, Rad51 and PARP.