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. 2015 Oct 2;6(32):33410–33425. doi: 10.18632/oncotarget.5418

Figure 7. CEBPA P30 contributes to TOPK upregulation in AML.

Figure 7

THP-1 cells were transfected with CEBPA siRNA; A. FLT3 and TOPK mRNA and B. protein levels were assessed 48 hours later. THP-1 cells transfected with either empty vector: EV, P30 or P42; C. TOPK and FLT3 mRNA expression and D. protein levels were assessed 48 hours later. E. A schematic figure showing the mechanism by which targeting TOPK could affect FLT3-ITD positive AML cells. Data are presented as Mean ± SEM, P values were calculated using Student's t-test (*p < 0.05).