Skip to main content
. 2015 Sep 10;6(32):33568–33586. doi: 10.18632/oncotarget.5598

Figure 6. Suppression of CXCR4 expression and migration of MM cells by MCT blockade.

Figure 6

A. MM cells were incubated for 16 hours with or without 5 mM CHC and then subjected to RT-PCR. B. MM cells were cultured in the presence (dotted line) or absence (solid line) of 4 mM CHC for 24 hours, stained with phycoerythrin-labeled anti-CXCR4 antibody, and then subjected to flow cytometry. Background staining with control IgG was shown in gray. C. MM cells were plated in upper chambers with 8-μm pore filters; rhSDF-1α (final concentration 30 nM), CHC (final concentration 5 mM) or FBS (final concentration 10%) was added as indicated. After 24 hours, cells that had migrated to the lower chambers were counted. Results from three independent experiments were shown as the mean +/− SD. *p value < 0.05.