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. 2015 Sep 16;6(32):33733–33742. doi: 10.18632/oncotarget.5254

Figure 4. Compound 8 had higher binding affinity to CAIX compared to CAII and CAXII.

Figure 4

Saturation binding curves for CAII, CAIX, and CAXII were generated. 5 nM of compound 8 was titrated by increasing concentrations of CAII, CAIX, and CAXII and the resultant fluorescence polarization (mP) was measured, with EC50 values calculated.