Table 3. Genotype distributions, odds ratios (OR) and 95% confidence intervals (CI) for the association between breast cancer susceptibility loci of FGFR3 and FGFR4 in 747 breast cancer cases and 716 controls.
| Genotype | Case (n=747) | Control (n=716) | OR (95%CI) | P | OR (95%CI)a | Pa |
|---|---|---|---|---|---|---|
| rs1966265 | ||||||
| AA | 168 (22.5) | 226 (31.6) | 1.000 | 1.000 | ||
| AG | 408 (54.6) | 364 (50.8) | 1.508 (1.181-1.926) | 0.001 | 1.581 (1.232-2.028) | 3*10−4 |
| GG | 171 (22.9) | 126 (17.6) | 1.826 (1.346-2.476) | 1*10-4 | 1.890 (1.387-2.576) | 5*10−5 |
| G allele | 750 (50.2) | 616 (43.0) | 1.335 (1.154-1.545) | 1*10-4 | 1.360 (1.173-1.577) | 5*10−5 |
| AG+GG | 579 (77.5) | 490 (68.4) | 1.590 (1.259-2.007) | 9*10-5 | 1.661 (1.310-2.106) | 3*10−5 |
| rs351855 | ||||||
| GG | 205 (27.4) | 270 (37.7) | 1.000 | 1.000 | ||
| GA | 404 (54.1) | 348 (48.6) | 1.529 (1.213-1.927) | 3*10-4 | 1.555 (1.230-1.967) | 2*10−4 |
| AA | 138 (18.5) | 98 (13.7) | 1.855 (1.352-2.544) | 1*10-4 | 1.899 (1.377-2.617) | 8*10−5 |
| A allele | 680 (45.5) | 544 (38.0) | 1.364 (1.177-1.580) | 4*10-5 | 1.382 (1.190-1.605) | 2*10−5 |
| GA+AA | 542 (72.6) | 446 (62.3) | 1.601 (1.284-1.996) | 3*10-5 | 1.631 (1.303-2.040) | 2*10−5 |
| rs2234909 | ||||||
| TT | 672 (90.0) | 638 (89.1) | 1.000 | 1.000 | ||
| TC | 71 (9.5) | 77 (10.8) | 0.875 (0.623-1.230) | 0.443 | 0.903 (0.639-1.276) | 0.563 |
| CC | 4 (0.5) | 1 (0.1) | 3.798 (0.423-34.068) | 0.233 | 3.884 (0.427-35.290) | 0.228 |
| C allele | 79 (5.3) | 79 (5.5) | 0.956 (.694-1.318) | 0.784 | 0.985 (.712-1.364) | 0.929 |
| TC+CC | 75 (10.0) | 78 (10.9) | 0.913 (0.653-1.276) | 0.594 | 0.942 (0.670-1.324) | 0.731 |
| rs3135848 | ||||||
| TT | 576 (77.1) | 553 (77.2) | 1.000 | 1.000 | ||
| TC | 157 (21.0) | 155 (21.6) | 0.972 (0.757-1.250) | 0.827 | 0.971 (0.753-1.252) | 0.821 |
| CC | 14 (1.9) | 8 (1.1) | 1.680 (0.699-4.036) | 0.246 | 1.619 (0.658-3.981) | 0.294 |
| C allele | 185 (12.4) | 171 (11.9) | 1.042 (.835-1.301) | 0.715 | 1.035 (.826-1.296) | 0.767 |
| TC+CC | 171 (22.9) | 163 (22.8) | 1.007 (0.789-1.286) | 0.954 | 1.002 (0.782-1.284) | 0.985 |
a
Adjusted for age, BMI, age at menarche and menopausal status.