Table 2. Differences in odds of individual grade 3/4 AEs between studies with available companion diagnostics and those without companion diagnostics.
AEs, adverse events, CI, confidence interval; OR, odds ratio
| Adverse event | Companion Diagnostics | No Companion Diagnostics | P for difference | ||||
|---|---|---|---|---|---|---|---|
| Number of included studies | OR | 95% CI | Number of included studies | OR | 95% CI | ||
| Anemia | 8 | 0.79 | 0.62-1.00 | 12 | 1.14 | 0.89-1.46 | 0.04 |
| Neutropenia | 10 | 0.39 | 0.33-0.44 | 10 | 1.40 | 1.20-1.63 | <0.001 |
| Thrombocytopenia | 5 | 5.18 | 3.09-8.66 | 12 | 1.66 | 1.23-2.22 | <0.001 |
| Diarrhea | 14 | 1.29 | 1.07-1.55 | 22 | 2.43 | 2.08-2.83 | <0.001 |
| Vomiting | 9 | 0.86 | 0.65-1.14 | 20 | 1.44 | 1.14-1.83 | 0.005 |
| Stomatitis | 7 | 1.53 | 0.78-3.02 | 14 | 2.59 | 2.01-3.33 | 0.16 |
| Cutaneous toxicity | 11 | 1.82 | 1.45-2.28 | 18 | 3.88 | 3.06-4.94 | <0.001 |
| Asthenia/Fatigue | 14 | 0.99 | 0.79-1.23 | 24 | 1.23 | 1.11-1.37 | 0.07 |
| Pulmonary/Dyspnea | 6 | 1.15 | 0.84-1.57 | 11 | 0.90 | 0.74-1.09 | 0.19 |
| Hypertension | 5 | 5.95 | 3.03-11.67 | 14 | 5.87 | 4.74-7.26 | 0.97 |
| Cardiac | 4 | 1.57 | 1.11-2.23 | 3 | 6.88 | 1.25-37.82 | 0.10 |
| Neuropathy | 3 | 0.64 | 0.40-1.01 | 3 | 1.60 | 1.20-2.12 | <0.001 |