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. 2015 Nov 9;6(37):39891–39907. doi: 10.18632/oncotarget.5359

Figure 5. Upregulation of INPP4B in melanoma cells is associated with loss of miR-494 and/or miR-599.

Figure 5

A. Total RNA from melanocytes and melanoma cells were subjected to qPCR analysis of INPP4B mRNA expression. The relative abundance of INPP4B mRNA in melanocytes was arbitrarily designated as 1. Data are represented as mean ± SEM of three individual experiments. B. A schematic illustration of base pairing between miR-494 and miR-599 and the 3′UTR of the INPP4B mRNA. Mutations of the binding regions for miR-494 and miR-599 at the INPP4B 3′UTR are also shown. C. Total RNA from HEMn-MP melanocytes and melanoma cells were subjected to qPCR analysis of miR-494 or miR-599 expression. The relative abundance of each miR in melanocytes was arbitrarily designated as 1. The data shown are mean ± SEM of three individual experiments.