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. 2015 Nov 9;6(37):39891–39907. doi: 10.18632/oncotarget.5359

Figure 7. Downregulation of miR-494 or miR-599 in melanoma cells is associated with DNA copy number reduction.

Figure 7

A. qPCR analysis of genomic DNA from HEMn-MP melanocytes and melanoma cells. The average copy number of each gene in melanocytes was arbitrarily designated as 1. The data shown are the mean ± SEM of three individual experiments. B. qPCR analysis of genomic DNA from HEMn-MP melanocytes and fresh melanoma isolates sampled according to the levels of INPP4B protein as shown in Figure 1C. The average copy number of each gene in melanocytes was arbitrarily designated as 1. The data shown are the mean ± SEM of three individual experiments. C. qPCR analysis of genomic DNA from HEMn-MP melanocytes, Mel-RM and ME4405 melanoma cells and fresh melanoma isolates. The average copy number of melanocytes was arbitrarily designated as 1. The data shown are the mean ± SEM of three individual experiments.