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. 2015 Oct 14;6(37):39960–39968. doi: 10.18632/oncotarget.5662

Figure 2. Avidity of endothelial epitope affects shear stress-dependent nanoparticle binding in vitro.

Figure 2

A–B. Expression of CD146 was significantly higher in tumor than in liver tissue. Quantitative analysis of CD146 mean fluorescence intensity (A) and representative immunofluorescence images (B). Scale bar (100 μm) as indicated. C. Differential nanoparticle binding to tumor and liver endothelium under flow. The nanoparticle binding to endothelium was significantly higher in tumor than in liver tissue both under high and low shear stress (p < 0.05), whereas the selectivity of nanoparticle binding (tumor/liver ratio) was increased at higher shear stress rates of 10 dyn/cm2. D. Representative immunofluorescence images of nanoparticle binding to tumor endothelium. Only autofluorescence (granules) was detected in liver tissue. Scale bar (100 μm) as indicated.