Table 3. Transcriptomics data on the components of PDHC and selected monocarboxylate transporters in the cell lines used in this study.

Category	Cell line \ mRNA	HEK293 (11)	T98G (7)		U87 (11)
		median ± SEM	median ± SEM	ttest (with HEK293)	median ± SEM	ttest (with HEK293)	ttest (with T98G)
PDHC catalytic and assembly components	PDHA1	0.472 ± 0.050	0.050 ± 0.041	0.0003	0.051 ± 0.032	0.0001	0.4780
	PDHB	0.148 ± 0.014	0.024 ± 0.013	0.0000	0.043 ± 0.018	0.0001	0.0823
	DLAT	0.157 ± 0.032	0.014 ± 0.011	0.0055	0.000 ± 0.001	0.0001	0.0002
	DLD	0.241 ± 0.024	0.148 ± 0.054	0.0035	0.067 ± 0.021	0.0000	0.0000
	PDHX	0.131 ± 0.011	0.059 ± 0.024	0.0003	0.023 ± 0.007	0.0000	0.0006
PDHC regulatory components	PDK1	0.009 ± 0.010	0.008 ± 0.004	0.0984	0.002 ± 0.004	0.1030	0.3568
	PDK2	0.024 ± 0.006	0.004 ± 0.003	0.0236	0.000 ± 0.001	0.0013	0.0734
	PDK3	0.015 ± 0.003	0.000 ± 0.001	0.0043	0.001 ± 0.000	0.0005	0.4215
	PDP1	0.019 ± 0.005	0.036 ± 0.011	0.2346	0.008 ± 0.005	0.0796	0.0849
	PDP2	0.014 ± 0.002	0.000 ± 0.000	0.0004	0.001 ± 0.000	0.0000	0.1580
Pyruvate and / or lactate carriers	SLC16A1	0.384 ± 0.028	0.042 ± 0.035	0.0000	0.020 ± 0.011	0.0000	0.0375
	SLC16A7	0.012 ± 0.003	0.012 ± 0.009	0.1714	0.001 ± 0.001	0.0086	0.0156
	SLC16A8	0.000 ± 0.000	0.087 ± 0.043	0.0001	0.166 ± 0.045	0.0001	0.2213
	SLC16A3	0.000 ± 0.000	0.000 ± 0.000	0.0331	0.001 ± 0.000	0.0032	0.3387
	MPC1	0.174 ± 0.018	0.039 ± 0.016	0.0000	0.051 ± 0.018	0.0001	0.2724
	MPC2	0.164 ± 0.025	0.067 ± 0.037	0.0198	0.209 ± 0.053	0.3819	0.0327

The relative expression levels of mRNAs of the annotated genes of interest were extracted from global transcriptomics data deposited in the GEO database. The numbers of experiments used for the calculations of median and SEM values are shown in parentheses.