Skip to main content
. 2015 Oct 12;6(37):40141–40157. doi: 10.18632/oncotarget.5653

Figure 1. PIM Inhibitors lack significant efficacy against MPN model cells.

Figure 1

A. The MPN model/JAK2-V617F-expressing cell lines HEL and SET2 were cultured with the indicated concentrations of the PIM inhibitor SGI-1776. Total viable cells were determined over time using trypan blue exclusion. B. The MPN/JAK2-V617F-expressing cells HEL, Uke1, and BaF3-JAK2-V617F were treated with a range of concentrations of the PIM inhibitor AZD1208 and relative viable cells were determined by MTS assay. Percent growth relative to DMSO control is plotted versus the log of AZD1208 concentration. Fifty percent growth/inhibition is indicated by a dashed line.