Table 1. Immune-specific cell-types (as per analysis in Bindea et al. [5]) for which a significant number of genes are up-regulated, and the genes up-regulated therein.
| NvD | DvT | ||
|---|---|---|---|
| Cell-type | Genes | Cell-type | Genes |
| aDC | LAMP3, OAS3 | Macrophages | MARCO, BCAT1, FN1, MSR1, SULT1C2, PCOLCE2, SCG5 |
| B-cells | BLK, KIAA0125, MS4A1, SCN3A, IGKC, SLC15A2, SPIB | Neutrophils | BST1, DYSF, FPR1, MME |
| Cytotoxic cells | APBA2, GNLY, GZMA, NKG7, RUNX3 | Tgd | C1orf61, FEZ1 |
| NK CD56 dim cells | IL21R, GZMB | Th1 cells | DGKI, DOK5, EGFL6, GGT1 |
| T-cells | LCK, CD2, CD28, CD3D, CD3E, CD6, SH2D1A | Th2 cells | MB, ADCY1, PTGIS, ANK1, PHEX |
| TFH | CXCL13, SIRPG, TOX | ||
| Th1 cells | BST2, CD38, CTLA4 | ||
Abbreviations: NvD: Normal versus Dysplasia. DvT: Dysplasia versus Tumour. aDC: activated Dendritic Cell. TFH: T Follicular Helper cell. Th1/2: T-helper 1/2 cell. Tgd: T gamma delta cell.