Table 1. Summary of GWA scan and replication studies for 4 SNPs consistent in three stages.

SNP	Study	Casesb	Controlsb	MAFc		ORadd	Padd	P–Qd
				Cases	Controls	(95% CI)
rs12522693	GWAS	16/242/673	13/172/780	0.15	0.10	1.55(1.27–1.89)	1.86 × 10−5
5q23.3	Replication I	34/404/1321	21/367/1487	0.13	0.11	1.27(1.10–1.46)	1.10 × 10−3
G/Aa	Replication II	16/212/715	18/360/1460	0.13	0.11	1.23(1.04–1.46)	1.61 × 10−2
	Combined All					1.31(1.19–1.45)	2.08 × 10−8	0.19
rs10035791	GWAS	23/272/635	17/208/740	0.17	0.13	1.51(1.25–1.82)	1.54 × 10−5
5q23.3	Replication I	42/463/1249	33/442/1386	0.16	0.14	1.17(1.03–1.33)	1.98 × 10−2
G/Aa	Replication II	23/252/668	31/433/1366	0.16	0.14	1.20(1.03–1.41)	2.10 × 10−2
	Combined All					1.25(1.14–1.36)	8.20 × 10−7	0.08
rs80007597	GWAS	13/230/688	9/162/793	0.14	0.09	1.59(1.29–1.96)	1.16 × 10−5
5q23.3	Replication I	27/386/1335	19/346/1493	0.13	0.10	1.25(1.08–1.45)	2.73 × 10−5
G/Ca	Replication II	14/201/726	29/329/1475	0.12	0.11	1.17(0.98–1.39)	7.64 × 10−2
	Combined All					1.29(1.17–1.42)	3.63 × 10−7	0.07
rs17836917	GWAS	6/130/796	21/179/765	0.08	0.11	0.64(0.51–0.80)	6.15 × 10−5
17q12	Replication I	12/308/1439	34/371/1470	0.09	0.12	0.79(0.68–0.92)	1.80 × 10−3
G/Aa	Replication II	7/159/777	21/379/1438	0.09	0.11	0.78(0.65–0.94)	9.43 × 10−3
	Combined All					0.75(0.68–0.83)	4.55 × 10−8	0.27

^aMajor/minor alleles

^bVariant homozygote/Heterozygote/Wild type homozygote

^cMinor allele frequency (MAF)

OR_add, P_add: calculated by additive model adjusted for age, gender and first ten PC

^dP value of Cochran's Q test.