Fig 1. Zinc is more absorbed by synoviocytes under inflammatory conditions.

(A) Zn concentration in the OA synoviocyte culture experiment as a function of time. Dashed line: control experiment with no cytokine addition. Solid line: cytokines added to the culture medium. (B) Zn concentration in the RA synoviocyte culture experiment as a function of time. Dashed and solid line as in A. (C) Zn uptake calculated from Zn concentration measured in the cells expressed in ng per 10⁶ cells at time t = 120 h. (D) K_D = (⁶⁶Zn/⁷⁰Zn)_cells/(⁶⁶Zn/⁷⁰Zn)_medium at 120h after addition of ultra-trace amounts of ⁷⁰Zn. At equilibrium, K_D =. Data are the mean of at least three independent experiments. Data are presented as mean ± SEM; * p<0.05.