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. 2016 Feb 4;11(2):e0147146. doi: 10.1371/journal.pone.0147146

Fig 3. Exposure to Zn and pro-inflammatory cytokines synergistically affect IL-6 production in RA synoviocytes.

Fig 3

OA and RA synoviocytes were treated overnight with IL-17A (50 ng/mL) and TNF-α (0.5 ng/mL) followed by the addition of different Zn concentrations (0.9 and 3.6 ppm). Supernatants were collected at day 1, 5 and 8. IL-6 production was quantified by ELISA. Statistical significance was assessed by a two-way Anova. Data are presented as mean ± SEM; # refers to the analysis of cytokine exposure, * to the analysis of Zinc exposure, § to the analysis of differences between OA and RA synoviocytes. */#/§ p<0.05, **/##/§§ p<0.01.