Table 3. Univariable and multivariable analyses of prognostic parameters for survival in Renji cohort 2 patients with pancreatic ductal adenocarcinoma (PDAC).
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Prognostic parameter | HR | 95% CI | P value | HR | 95% CI | P value |
| Expression of RPL15 (low vs. high) | 0.407 | 0.286-0.580 | 0.000 | 0.461 | 0.322-0.659 | 0.000 |
| Age (<65 vs. ≥65) | 1.466 | 1.038-2.070 | 0.030 | 1.682 | 1.172-2.415 | 0.005 |
| Gender (male vs. female) | 0.757 | 0.531-1.079 | 0.124 | - | - | - |
| Tumor Size (≤2 cm vs. >2 cm) | 2.211 | 1.220-4.006 | 0.009 | 1.961 | 1.042-3.692 | 0.037 |
| T classification (T1-2 vs. T3-4) | 1.330 | 1.033-1.713 | 0.027 | 0.997 | 0.728-1.365 | 0.984 |
| Lymph node metastasis (absent vs. present) | 1.628 | 1.143-2.317 | 0.007 | 1.579 | 1.069-2.332 | 0.022 |
| Distant metastasis (absent vs. present) | 1.923 | 1.029-3.594 | 0.040 | 2.086 | 1.100-3.959 | 0.024 |
| Vascular invasion (absent vs. present) | 1.554 | 0.954-2.532 | 0.077 | - | - | - |
| Tumor location (head vs. body/tail) | 0.983 | 0.683-1.416 | 0.928 | - | - | - |
| Histology (well vs. moderate/poor) | 2.566 | 1.047-6.289 | 0.039 | 2.872 | 1.142-7.220 | 0.025 |
| CA199 level (≤35 U/ml vs. >35 U/ml) | 1.411 | 0.817-2.438 | 0.217 | - | - | - |
HR: Hazard ratio; CI: Confidence interval. The bold number represents the P-values with significant differences.