Table 2. Specific ubiquitinated proteins known to be degraded by macroautophagy.
Protein | Protein types | Autophagy receptor | E3 ligase | Ub chains | Ref |
---|---|---|---|---|---|
AGO2 | Native | NDP52 | Unkown | Unkown | [71] |
ARTD10 | Aggregates | p62 | Unkown | Unkown | [72] |
DICER1 | Native | NDP52 | Unkown | Unkown | [71] |
Dvl2 | Aggregates | p62 | VHL | K63 | [73] |
HIF2A | Aggregates | p62 | VHL | Unkown | [74] |
HTT | Aggregates | TOLLIP | Rsp5 | K48 and K63 | [64] |
NFKBIA | Aggregates | p62 | Unkown | Unkown | [75] |
p53 | Aggregates | p62 | MDM2 | K63 | [70] |
p65 | Aggresomes | p62 | Unkown | Unkown | [76] |
RHOA | Native | p62 | Unkown | Unkown | [77] |
TFRC | Native | OPTN | Unkown | Unkown | [78] |