Table 3. Specific non-ubiquitinated proteins known to be degraded by macrcoautophagy.
| Protein | Protein types | Autophagy degradation model | Ref |
|---|---|---|---|
| APP | Native state | APP-AP2-LC3 | [85] |
| AR | Aggregates | AR-p62-LC3B | [86] |
| BCR-ABL | Native state | BCR-ABL-p62 | [87] |
| BiP | Native state | BiP-p62-LC3B | [88] |
| CTNNB1 | Native state | CTNNB1-LC3B | [89] |
| FAP1 | Native state | FAP1-p62 | [90] |
| Ferritin | Native state | Ferritin - NCOA4- LC3/ GABARAP | [91] |
| HTT | Native state Aggregates |
HTT-GABARAPL1/p62-LC3B HTT-OPTN-LC3 |
[92,93] [94] |
| Keap1 | Native state | Keap1-p62-LC3 | [95] |
| MAPT | Native state | MAPT-NDP52-LC3 | [96] |
| PrP | Aggregates | PrP-p62-LC3B | [97] |
| SOD1 | Aggregates | SOD1-p62/OPTN-LC3 | [94,98] |
| Src | Native state | Src-c-Cbl-LC3B | [99] |
| STAT5A | Oligomers | STAT5A-p62-LC3 | [100] |
| TP53INP1 | Native state | TP53INP1-LC3/ GABARAP | [101] |
| VPRBP | Native state | VPRBP-p62-LC3B | [102] |