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. 2015 Oct 15;6(35):37257–37268. doi: 10.18632/oncotarget.6133

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Copyright: © 2015 Jung et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Oncomine analysis of WNT ligands in CRC. P value < 0.0001; fold change > 2. TCGA CRC datasets. B. Oncomine analysis of WNT2 expression in CRC datasets. P value < 0.0001; fold change > 2. Dataset information: 1. Rectal Adenocarcinoma vs. Normal / Gaedcke Colorectal, Genes Chromosomes Cancer, 2010; 2. Colorectal Adenoma Epithelia vs. Normal / Gaspar Colon, Am J Pathol, 2008; 3. Colorectal Carcinoma vs. Normal / Graudens Colon, Genome Biol, 2006; 4. Colorectal Carcinoma vs. Normal / Hong Colorectal, Clin Exp Metastasis, 2010; 5. Cecum Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 6. Colon Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 7. Colon Mucinous Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 8. Rectal Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 9. Rectal Mucinous Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 10. Rectosigmoid Adenocarcinoma vs. Normal / Kaiser Colon, Genome Biol, 2007; 11. Colon Adenocarcinoma vs. Normal / Ki Colon, Int J Cancer, 2007; 12. Colon Adenocarcinoma vs. Normal / Notterman Colon, Cancer Res, 2001; 13. Colon Adenoma vs. Normal / Sabates-Bellver Colon, Mol Cancer Res, 2007; 14. Rectal Adenoma vs. Normal / Sabates-Bellver Colon, Mol Cancer Res, 2007; 15. Colorectal Adenocarcinoma vs. Normal / Skrzypczak Colorectal, PLoS One, 2010; 16. Colorectal Carcinoma vs. Normal / Skrzypczak Colorectal, PLoS One, 2010; 17. Colon Adenoma Epithelia vs. Normal / Skrzypczak Colorectal 2, PLoS One, 2010; 18. Colon Adenoma vs. Normal / Skrzypczak Colorectal 2, PLoS One, 2010; 19. Colon Carcinoma Epithelia vs. Normal / Skrzypczak Colorectal 2, PLoS One, 2010; 20. Colon Carcinoma vs. Normal / Skrzypczak Colorectal 2, PLoS One, 2010; 21. Cecum Adenocarcinoma vs. Normal / TCGA Colorectal, Nature, 2012; 22. Colon Adenocarcinoma vs. Normal / TCGA Colorectal, Nature, 2012; 23. Colon Mucinous Adenocarcinoma vs. Normal / TCGA Colorectal, Nature, 2012; 24. Rectal Adenocarcinoma vs. Normal / TCGA Colorectal, Nature, 2012; 25. Rectal Mucinous Adenocarcinoma vs. Normal / TCGA Colorectal, Nature, 2012; 26. Colon Carcinoma vs. Normal / Zou Colon, Oncogene, 2002. C. Wnt2 expression in human CRC tissues. Human CRC tissue microarray was analyzed for Wnt2 expression by immunofluorescent staining. 4′,6-diamidino-2-phenylindole, dihydrochloride (DAPI): nuclear counterstaining. D. Expression of Wnt2 protein in non-CRC (FHC and CCD841CoN) and CRC cell lines. IB analysis.