Figure 4. Silencing ILT2 restores the proliferation of NK cells.

Parental and modified NK cells were co-cultured with tumor cells with or without HLA-G expression (upper panel-A K562, lower panel-B LCL). Proliferation of NK-10 (ILT2⁻ NKL cells) (striped bars) and NKL (black bars) were evaluated using luminescent, ATP-based assays. Data are representative of one out of three independent experiments performed and show the means ± SD, p < 0.01 was considered to be significant.