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. 2015 Oct 9;6(35):37385–37397. doi: 10.18632/oncotarget.6044

Figure 6. Silencing ILT2 restores the cytotoxic activity.

Figure 6

NKL and NK-10 (ILT2− NKL cells) co-cultured with K562 and K562g or LCL and LCLg cells were stained with anti-CD107a, anti-CD56, and isotype controls and analyzed by flow cytometry (upper panel) A.. K562g cells (grey bars) or K562 cells (black bars) were used to test the killing potential of NKL (bottom left panel) and NK-10 (bottom center panel) B.. Comparison of the lytic function of NK-10 cells against LCLg targets with that of NKL cells against blocking anti-ILT2 or anti-HLA-G mAbs-treated LCLg targets (bottom right panel) C.. Results shown in A. are from one representative experiment out of three performed. Figures B. and C. show the means ± SD of three independent experiments performed, p < 0.01 was considered to be significant.