Table 3. Summary results of diagnostic accuracy of urine BLCA-4 for bladder cancer.
| Subgroup | No. of Studies (No. of cases) | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|---|
| Ethnicity | |||||||
| USA | 2 (246) | 0.92 (0.86, 0.96) | 0.97 (0.93, 0.99) | 30.47 (10.90, 85.19) | 0.08 (0.05, 0.15) | 301.54 (91.12, 997.85) | -- |
| China | 7 (873) | 0.93 (0.90, 0.95) | 0.97 (0.95, 0.98) | 56.61 (7.60, 421.82) | 0.08 (0.06, 0.11) | 631.46 (117.35, 3397.91) | 0.9622 |
| Sample size | |||||||
| > 100 | 6 (873) | 0.93 (0.90, 0.95) | 0.96 (0.94, 0.98) | 47.67 (7.55, 301.02) | 0.08 (0.06, 0.11) | 583.35 (105.68, 3219.94) | 0.9623 |
| ≤ 100 | 3 (246) | 0.91 (0.84, 0.95) | 0.99 (0.96, 1.00) | 48.12 (13.15,176.07) | 0.09 (0.05, 0.17) | 444.90 (97.10, 2038.54) | 0.8594 |
| Assay method | |||||||
| Sandwich immunoassay | 1 (140) | -- | -- | -- | -- | -- | -- |
| QPCR | 1 (155) | -- | -- | -- | -- | -- | -- |
| ELISA test | 7 (824) | 0.94 (0.91, 0.96) | 1.00 (0.99, 1.00) | 91.56 (35.79, 234.23) | 0.07 (0.05, 0.10) | 1094.47 (367.11, 3262.95) | 0.9780 |
| Cut off value | |||||||
| 0.04 (OD) | 1 (140) | -- | -- | -- | -- | -- | |
| 1.7×10−4 A | 1 (136) | -- | -- | -- | -- | -- | |
| 13 A /ug | 7 (843) | 0.92 (0.89, 0.95) | 0.97 (0.95, 0.98) | 55.03 (7.66, 395.23) | 0.09 (0.07, 0.13) | 583.04 (113.54, 2993.93) | 0.9612 |
| Total | 9(1119) | 0.93 (0.90, 0.95) | 0.97 (0.95, 0.98) | 48.16 (11.77, 197.01) | 0.08 (0.06, 0.11) | 534.03 (150.15, 1899.31) | 0.9607 |
ELISA, Enzyme Linked Immunosorbent Assay; QPCR, Quantitative Polymerase Chain Reaction; OD, Absorbance units; CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve.