Table 1. Clinical-pathological characteristics of the overall CRC patient cohort and their association with levels of OX40+ infiltrate.
Total N=657* |
OX40 low N=440* |
OX40 high N=217* |
OX40 low vs high | ||||
---|---|---|---|---|---|---|---|
Characteristics | N or mean | (% or range) | N or mean | (% or range) | N or mean | (% or range) | P** |
Age, years (median, mean) | 71, 69.9 | (36-96) | 72, 70.5 | (36-96) | 70, 68.6 | (40-90) | 0.02 |
Tumor size in mm (median, mean) | 50, 51.7 | (5-170) | 45, 51.5 | (5-170) | 50, 50.2 | (7-160) | 0.827 |
Sex | 0.539 | ||||||
Female (%) | 359 | (54.6) | 247 | (56.1) | 112 | (51.6) | |
Male (%) | 298 | (45.4) | 193 | (43.9) | 105 | (48.4) | |
Anatomic site of the tumor | 0.037 | ||||||
Left-sided (%) | 425 | (64.7) | 272 | (61.8) | 153 | (70.5) | |
Right-sided (%) | 228 | (34.7) | 165 | (37.5) | 63 | (29.0) | |
T stage | |||||||
T1 (%) | 29 | (4.4) | 11 | (2.5) | 18 | (8.3) | <0.0001 |
T2 (%) | 103 | (15.7) | 62 | (14.1) | 41 | (18.9) | |
T3 (%) | 416 | (63.3) | 284 | (64.5) | 132 | (60.8) | |
T4 (%) | 91 | (13.8) | 74 | (16.8) | 17 | (7.8) | |
N stage | |||||||
N0 (%) | 333 | (50.7) | 203 | (46.1) | 130 | (59.9) | 0.002 |
N1 (%) | 174 | (26.5) | 127 | (28.9) | 47 | (21.7) | |
N2 (%) | 128 | (19.5) | 97 | (22.0) | 31 | (14.3) | |
Tumor grade | 0.739 | ||||||
G1 (%) | 15 | (2.2) | 9 | (2.0) | 6 | (2.8) | |
G2 (%) | 562 | (85.5) | 377 | (85.7) | 185 | (85.2) | |
G3 (%) | 60 | (9.1) | 42 | (9.6) | 18 | (8.3) | |
UICC | |||||||
Stage IA (%) T1N0 | 21 | (3.2) | 9 | (2.0) | 12 | (5.5) | 0.0003 |
Stage IB (%) T2N0 | 73 | (11.1) | 44 | (10.0) | 29 | (13.4) | |
Stage IIA (%) T3N0 | 202 | (30.7) | 123 | (30.0) | 79 | (36.4) | |
Stage IIB-C (%) T4N0 | 30 | (4.6) | 25 | (5.7) | 5 | (2.3) | |
Stage III (%) N+ | 296 | (45.1) | 220 | (50.0) | 76 | (35.0) | |
Tumor border configuration | |||||||
Infiltrative (%) | 418 | (63.6) | 285 | (64.8) | 133 | (61.3) | 0.568 |
Pushing (%) | 218 | (33.2) | 143 | (32.5) | 75 | (34.6) | |
Vascular invasion | |||||||
No (%) | 462 | (70.3) | 300 | (68.2) | 162 | (74.7) | 0.044 |
Yes (%) | 175 | (26.6) | 129 | (29.3) | 46 | (21.2) | |
Microsatellite Stability | |||||||
Proficient (%) | 552 | (84.0) | 362 | (82.3) | 190 | (87.6) | 0.104 |
Deficient (%) | 105 | (16.0) | 78 | (17.7) | 27 | (12.4) | |
Rectal cancers (%) | 219 | (33.3) | 131 | (29.8) | 88 | (40.6) | 0.013 |
Rectosigmoid cancers (%) | 41 | (6.2) | 33 | (7.5) | 8 | (3.7) | |
Median overall survival time (months) | 92 | 0-152 | 77 | 0-152 | 101 | 0-150 | <0.0001 |
5-year overall survival % (95%CI) | 55.4 | 51.6–59.6 | 49.9 | 45.2–55.1 | 66.1 | 59.9–72.9 | 0.0003 |
Percentages may not add to 100% due to missing values of defined variables.
Age and tumor size were evaluated using the Mann–Whitney test. Gender, anatomical site, T stage, N stage, grade, vascular invasion, and tumor border configuration were analyzed using the χ2 or Fisher exact test depending on the number of observations. Survival analysis was performed using the Kaplan-Meier method and comparatively analyzed with the log-rank test.