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. 2015 Sep 29;6(35):37588–37599. doi: 10.18632/oncotarget.5940

Table 1. Clinical-pathological characteristics of the overall CRC patient cohort and their association with levels of OX40+ infiltrate.

Total
N=657*
OX40 low
N=440*
OX40 high
N=217*
OX40 low vs high
Characteristics N or mean (% or range) N or mean (% or range) N or mean (% or range) P**
Age, years (median, mean) 71, 69.9 (36-96) 72, 70.5 (36-96) 70, 68.6 (40-90) 0.02
Tumor size in mm (median, mean) 50, 51.7 (5-170) 45, 51.5 (5-170) 50, 50.2 (7-160) 0.827
Sex 0.539
Female (%) 359 (54.6) 247 (56.1) 112 (51.6)
Male (%) 298 (45.4) 193 (43.9) 105 (48.4)
Anatomic site of the tumor 0.037
Left-sided (%) 425 (64.7) 272 (61.8) 153 (70.5)
Right-sided (%) 228 (34.7) 165 (37.5) 63 (29.0)
T stage
T1 (%) 29 (4.4) 11 (2.5) 18 (8.3) <0.0001
T2 (%) 103 (15.7) 62 (14.1) 41 (18.9)
T3 (%) 416 (63.3) 284 (64.5) 132 (60.8)
T4 (%) 91 (13.8) 74 (16.8) 17 (7.8)
N stage
N0 (%) 333 (50.7) 203 (46.1) 130 (59.9) 0.002
N1 (%) 174 (26.5) 127 (28.9) 47 (21.7)
N2 (%) 128 (19.5) 97 (22.0) 31 (14.3)
Tumor grade 0.739
G1 (%) 15 (2.2) 9 (2.0) 6 (2.8)
G2 (%) 562 (85.5) 377 (85.7) 185 (85.2)
G3 (%) 60 (9.1) 42 (9.6) 18 (8.3)
UICC
Stage IA (%) T1N0 21 (3.2) 9 (2.0) 12 (5.5) 0.0003
Stage IB (%) T2N0 73 (11.1) 44 (10.0) 29 (13.4)
Stage IIA (%) T3N0 202 (30.7) 123 (30.0) 79 (36.4)
Stage IIB-C (%) T4N0 30 (4.6) 25 (5.7) 5 (2.3)
Stage III (%) N+ 296 (45.1) 220 (50.0) 76 (35.0)
Tumor border configuration
Infiltrative (%) 418 (63.6) 285 (64.8) 133 (61.3) 0.568
Pushing (%) 218 (33.2) 143 (32.5) 75 (34.6)
Vascular invasion
No (%) 462 (70.3) 300 (68.2) 162 (74.7) 0.044
Yes (%) 175 (26.6) 129 (29.3) 46 (21.2)
Microsatellite Stability
Proficient (%) 552 (84.0) 362 (82.3) 190 (87.6) 0.104
Deficient (%) 105 (16.0) 78 (17.7) 27 (12.4)
Rectal cancers (%) 219 (33.3) 131 (29.8) 88 (40.6) 0.013
Rectosigmoid cancers (%) 41 (6.2) 33 (7.5) 8 (3.7)
Median overall survival time (months) 92 0-152 77 0-152 101 0-150 <0.0001
5-year overall survival % (95%CI) 55.4 51.6–59.6 49.9 45.2–55.1 66.1 59.9–72.9 0.0003
*

Percentages may not add to 100% due to missing values of defined variables.

**

Age and tumor size were evaluated using the Mann–Whitney test. Gender, anatomical site, T stage, N stage, grade, vascular invasion, and tumor border configuration were analyzed using the χ2 or Fisher exact test depending on the number of observations. Survival analysis was performed using the Kaplan-Meier method and comparatively analyzed with the log-rank test.