Table 2. Effects of 14 tag SNPs from eight RNA splicing-related genes on PC risk in the screening population.
| Gene | SNP | Genotypesa | Controls (N = 525) (%) | Cases (N = 298) (%) | OR (95%CI)b | P | FDR-Pc |
|---|---|---|---|---|---|---|---|
| PRPF40B | rs4073998 | (AA+AG)/GG | 65(12.4)/460(87.6) | 59(19.8)/239(80.2) | 1.80(1.22–2.67) | 0.003 | 0.014* |
| rs8626 | (GG+AG)/AA | 71(13.5)/454(86.5) | 78(26.2)/220(73.8) | 2.37(1.64–3.41) | 3.9E-06 | 5.5E-05* | |
| SF1 | rs474707 | (TT+CT)/CC | 320(61.0)/205(39.0) | 178(59.7)/120(40.3) | 0.96(0.71–1.28) | 0.757 | 0.815 |
| SF3A1 | rs12484880 | (GG+TG)/TT | 76(14.5)/449(85.5) | 47(15.8)/251(84.2) | 1.11(0.74–1.66) | 0.610 | 0.712 |
| rs2074733 | (TT+CT)/CC | 366(69.7)/159(30.3) | 179(60.1)/119(39.9) | 0.65(0.48–0.88) | 0.005 | 0.014* | |
| rs5753081 | CT/CC | 29(5.5)/496(94.5) | 15(5.0)/283(95.0) | 0.97(0.51–1.85) | 0.928 | 0.928 | |
| rs5994293 | GG/GT/TT | 56(10.7)/200(38.1)/269(51.2) | 19(6.4)/102(34.2)/177(59.4) | 0.74(0.59–0.93) | 0.01 | 0.023* | |
| rs7288947 | (TT+CT)/CC | 166(31.6)/359(68.4) | 76(25.5)/222(74.5) | 0.75(0.54–1.03) | 0.075 | 0.131 | |
| rs8141656 | (CC+CT)/TT | 261(49.7)/264(50.3) | 164(55.0)/134(45.0) | 1.25(0.94–1.67) | 0.130 | 0.202 | |
| rs9608886 | (GG+TG)/TT | 113(21.5)/412(78.5) | 40(13.4)/258(86.6) | 0.55(0.37–0.82) | 0.004 | 0.014* | |
| SF3B1 | rs11683572 | (GG+CG)/CC | 222(42.3)/303(57.7) | 108(36.2)/190(63.8) | 0.74(0.55–1.00) | 0.047 | 0.094 |
| SRSF1 | rs2233911 | (GG+AG)/AA | 170(32.4)/355(67.6) | 114(38.3)/184(61.7) | 1.25(0.92–1.68) | 0.151 | 0.211 |
| rs8819 | CT/CC | 21(4.0)/504(96.0) | 32(10.7)/266(89.3) | 3.04(1.69–5.48) | 2.1E-04 | 0.001* | |
| SRSF2 | rs237059 | CT/CC | 6(1.1)/519(98.9) | 1(0.3)/297(99.7) | 0.26(0.03–2.18) | 0.212 | 0.270 |
a
The last genotype was used as the reference for OR estimation.
b
Adjusted by gender, age, smoking and drinking in the unconditional logistic regression.
c
Each P value was modified by FDR correction for multiple comparisons (the number of comparisons = 14).
*
Significant difference after FDR correction