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. 2015 Oct 14;6(35):37808–37823. doi: 10.18632/oncotarget.5676

Figure 7. miR-149 suppresses HCC metastasis in vivo.

Figure 7

A. The effects of miR-149 on HCC metastasis. HepG2 cells transduced with miR-149 expression lentivirus or negative control lentivirus were used to generate the mouse model. Images show the fluorescence of lung metastases photographed with a whole-body fluorescent imaging system. B. Hematoxylin and eosin staining was performed to identify HCC lung metastases, and representative sections of lung metastases are shown. The number of lung metastatic nodules distinctly decreased in the miR-149 expression group. C. Immunohistochemical staining of lung metastasis sections was performed to analyze the expression of PPM1F. Representative images show that the expression of PPM1F decreased in the miR-149 expression group.