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. 2015 Oct 8;6(35):37824–37835. doi: 10.18632/oncotarget.5637

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Copyright: © 2015 de Lange et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Karyograms of 06-023 revealed monosomy 3 heterogeneity while homogeneous isochromosome 8q indicated that it preceded monosomy 3 A. UM 20-042 displayed heterogeneity for monosomy 3 and loss of 1p, indicated by circles that represent the fractions of the tumor containing a specific chromosomal aberration B. Integration of tumor heterogeneity with gene-expression classes suggested distinct chronology in UM development in class I and class II C. Two UM in class I did not contain 6p gain but presented L1p and M3/8q+ genotypes respectively. The class II UM without gain of 8q did present monosomy 3.