Table 3. Frequently altered proteins in OCI-AML3 and MOLM-16 cells after treatment with AZD1208, AZD2014, or the combination*.
| AZD1208 | |||
| GeneSymbol | Protein name | Fold changes | |
| OCI-AML3 | MOLM16 | ||
| ALBU | Serum albumin | 1.8762 | 1.3757 |
| RPN1 | ribophorin I | 0.9292 | 1.1966 |
| HSP7C | Heat shock cognate 71 kDa protein | 0.9089 | 0.7391 |
| EF1A1 | Elongation factor 1-alpha 1 | 0.8668 | 0.7897 |
| AZD2014 | |||
| GeneSymbol | Protein name | Fold changes | |
| OCI-AML3 | MOLM16 | ||
| 1-/S90A | Isoform 2 of Heat shock protein HSP 90-alpha | 0.9327 | 0.9098 |
| EF2 | eukaryotic translation elongation factor 2 | 0.8673 | 0.9314 |
| DNJA1 | DnaJ homolog subfamily A member 1 | 0.7815 | 0.7554 |
| NP1L1 | Nucleosome assembly protein 1-like 1 | 0.857 | 0.7198 |
| AZD1208/AZD2014 combination | |||
| GeneSymbol | Protein name | Fold changes | |
| OCI-AML3 | MOLM16 | ||
| ALBU | Serum albumin | 2.434 | 1.8055 |
| RPN1 | ribophorin I | 0.912 | 1.1888 |
| HMGS f | high mobility group box 1 | 1.1893 | 1.1948 |
| HSP7C | Heat shock cognate 71 kDa protein | 0.8319 | 0.8472 |
| EF2 | Elongation factor 2 | 0.8615 | 0.8857 |
| GLU2B | Glucosidase 2 subunit beta | 1.1713 | 1.319 |
| HMGB2 | High mobility group protein B2 | 1.1918 | 1.2797 |
| DNJA1 | DnaJ homolog subfamily A member 1 | 0.7526 | 0.6752 |
| PHB | prohibitin | 1.1208 | 1.8256 |
| MDHM | Malate dehydrogenase, mitochondrial | 1.1328 | 1.2432 |
| FAS | Fatty acid synthase | 0.859 | 0.8684 |
| ACLY | ATP citrate lyase | 0.9216 | 0.8802 |
| NP1L 1 | Nucleosome assembly protein 1-like 1 | 0.8495 | 0.7276 |
| 1F4A1 | Eukaryotic initiation factor 4A-I | 0.841 | 0.7729 |
| CH10 | 10 kDa heat shock protein, mitochondrial | 1.1281 | 1.2642 |
| RS4X | 40S ribosomal protein S4, X isoform | 0.888 | 0.8417 |
| H4 | histone cluster 1, H4f | 2.0811 | 2.8924 |
| EF1A1 | Elongation factor 1-alpha 1 | 0.7936 | 0.8127 |
| RL24 | 60S ribosomal protein L24 | 1.3691 | 0.8494 |
| HS105 | Heat shock protein 105 kDa | 0.8455 | 0.8865 |
*
Detected by iTRAQ. Expression of all proteins listed was significantly different (P < 0.05) between controls and cells treated with AZD1208, AZD2014, or the combination. Values indicate fold-changes relative to untreated cells. Confidence score (a percentage measure of the confidence of the protein identification) for all proteins in the table was 99%.