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. 2015 Oct 12;6(35):37965–37978. doi: 10.18632/oncotarget.5700

Figure 3. Lapatinib induced IL-6 expression through MAPK signaling pathways.

Figure 3

A. Total proteins extracted from 231 and 231/Lap cells were subjected to western blotting analysis with indicated antibodies. B. and C. 231/Lap cells were treated with PD98059 (10 μM), U0126 (10 μM), AZD6244 (500 nM), SP600125 (30 μM), SB203580 (20 μM) and SB202190 (10 μM) for 2 days, followed by examination of IL-6 protein (B) and mRNA (C) expressions in ELISA and RT-qPCR analyses, respectively *: p < 0.05; **: p < 0.01 as compared with control group.