Table 1. Characteristics of study population.
| Discovery set (n = 7)a | Validation Set I (n = 114)b | Validation Set II (n = 313)c | |
|---|---|---|---|
| Age at surgery (mean ± SD) | 56.00 ± 5.01 | 58.96 ± 9.35 | 57.68 ± 9.49 |
| Sex | |||
| male | 7(100.00%) | 69(60.52%) | 180(57.51%) |
| female | 0(0.00%) | 45(39.48%) | 133(42.49%) |
| BMI(mean ± SD) | 22.14 ± 4.12 | 22.04 ± 5.78 | 23.17 ± 3.19 |
| Smoking Status | |||
| No | 0(0.00%) | 55(48.25%) | 155(49.52%) |
| Yes | 7(100.00%) | 59(51.75%) | 158(50.48%) |
| Smoking indexd | |||
| ≤ 20 | 1(14.29%) | 14(24.56%) | 42(27.10%) |
| > 20 | 6(85.71%) | 43(75.44%) | 113(72.90%) |
| Alcohol use | |||
| No | 5(71.43%) | 79(69.30%) | 220(70.29%) |
| Yes | 2(28.57%) | 35(30.70%) | 93(29.71%) |
| TNM stage | |||
| I | 0(0.00%) | 19(17.76%) | 78(24.92%) |
| II | 4(57.14%) | 20(18.69%) | 65(20.77%) |
| III | 3(42.86%) | 55(51.40%) | 127(40.58%) |
| IV | 0(0.00%) | 13(12.15%) | 43(13.74%) |
| Family history of cancer | |||
| No | 7(100.00%) | 97(85.09%) | 274(87.54%) |
| Yes | 0(0.00%) | 17(14.91%) | 39(12.46%) |
| Postoperative chemotherapy | |||
| No | 4(57.14%) | 64(56.14%) | 134(42.81%) |
| Yes | 3(42.86%) | 50(43.86%) | 179(57.19%) |
| Postoperative radiotherapy | |||
| No | 5(71.43%) | 84(73.68%) | 229(73.16%) |
| Yes | 2(28.57%) | 30(26.32%) | 84(26.84%) |
| Recurrence | |||
| No | 2(28.57%) | 108(94.74%) | 286(91.37%) |
| Yes | 5(71.43%) | 6(5.26%) | 27(8.63%) |
| Metastasis | |||
| No | 4(57.14%) | 84(73.68%) | 228(72.84%) |
| Yes | 3(42.86%) | 30(26.32%) | 85(27.16%) |
| Death | |||
| No | 4(57.14%) | 59(51.75%) | 200(63.90%) |
| Yes | 3(42.86%) | 55(48.25%) | 113(36.10%) |
a
Discovery set was used to screen copy number variations correlated with lung adenocarcinoma
b
Validation set I was used to verify the frequency of target copy number variations
c
Validation set II was used to detect the correlation between target copy number variations and lung adenocarcinoma survival
d
Smoking index = cigarette per day × smoking years