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. 2015 Oct 19;6(35):38046–38060. doi: 10.18632/oncotarget.5710

Figure 5. RNA-binding motif 4 [RBM4]-regulated splicing cascade modulates the activity of AKT/ERK signaling.

Figure 5

A. HCT-8 cells were transfected with an RBM4-expressing vector or siRNA against neuronal polypyrimidine tract-binding protein [nPTB]. B. HCT-116 cells were transfected with an nPTB- or miR92a-2-expressing vector or targeting vector of RBM4. The protein extract was extracted followed by an immunoblot analysis with the indicated antibodies. The bar graph presents the relative levels of phosphor-AKT and ERK protein using TotalLab Quant Software in three independent experiments.