Skip to main content
. 2015 Oct 16;6(35):38061–38078. doi: 10.18632/oncotarget.5706

Figure 1. CDC25A is an early cell cycle target downstream of FLT3-ITD.

Figure 1

a. MV4-11 (left panel) and MOLM-14 (right panel) FLT3-ITD expressing cells were treated for 2 hours with FLT3 inhibitor III (100 nM), and the protein levels of CDC25A, CDC25B, CDC25C, Cyclin A, Cyclin D1 and p27Kip1 were analyzed by western blot. b. MOLM-14 (FLT3-ITD positive), KG1 and HL-60 (FLT3wt positive) and K562 (FLT3 negative) cell lines were treated for 2 hours with FLT3 inhibitor III and the level of CDC25A was analyzed by western blot. Actin was used as a loading control. These results are representative of three independent experiments. ns: non specific.