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. 2015 Oct 13;6(35):38093–38106. doi: 10.18632/oncotarget.5642

Figure 1. HBV upregulates miR-331-3p expression by enhancing its promoter activity.

Figure 1

A–C. Relative miR-331-3p expression in HepG2 and HepG2.2.15 cells (A), SMMC7721 cells transfected with pCH9 or pCH9/3091 plasmids (B) and HepAD38 cells with/without Tet treatment (C) miRNA was normalized to U6 RNA. D. HBsAg and HBeAg expression in HCC cell lines. E. miR-331-3p promoter activity in SMMC7721 cells transfected with pCH9 or pCH9/3091 measured by Dual luciferase reporter analysis. F. miR-331-3p promoter activity in SMMC7721 cells co-transfected with DNAs or RNAs as indicated and measured by Dual luciferase reporter analysis. *P < 0.05, **P < 0.01.