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. 2015 Oct 15;6(35):38139–38150. doi: 10.18632/oncotarget.5709

Figure 3. Overexpression of miR-124 or miR-506 inhibits tumor cell proliferation and invasion in vivo.

Figure 3

A. SW620 cells infected with miR-124, miR-506 or scramble control were subcutaneously injected into the flanks of nude mice (n = 5 for each group). After injection, the average tumor volume was measured every four days until the mice were killed 28 days later. The growth curves of the tumors were then plotted. All data are presented as the mean ± s.e.m., ***P < 0.001. B. After 28 days, all mice were euthanized to excise the xenograft. Necropsies were performed, and the tumors were weighed. All data are presented as the mean ± s.e.m., *P < 0.05. C. Number of lung metastases per section. The number of metastatic nodules in five mice in each team was counted under the microscope. *P < 0.05. D. Representative images of lung metastasis of the miR-124-overexpressing, miR-506-overexpressing and scrambled control groups. Scale bars: 100 μm.