Table 3. Angiogenic-associated proteins identified in tumour xenografts in response to anti-tumour treatments.
| HT-29b | LIM1215b | |||||||
|---|---|---|---|---|---|---|---|---|
| Protein Acca | Gene Namea | Protein Descriptiona | Rsc (PBS v bevacizumab) | Rsc (PBS v cetuximab) | Rsc (PBS v Combination) | Rsc (PBS v bevacizumab) | Rsc (PBS v cetuximab) | Rsc (PBS v Combination) |
| P06576 | ATP5B | ATP synthase subunit beta, mitochondrial | −25.7 | −1.7 | −8.5 | 10.7 | 11.5 | 13.3 |
| P06733 | ENO1 | Alpha-enolase | −3.0 | 1.1 | −2.3 | 20.7 | 7.9 | 22.8 |
| Q15582 | TGFBI | Transforming growth factor-beta-induced protein ig-h3 | −1.5 | 1.1 | −1.3 | −1.1 | 4.9 | −1.0 |
| P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 1.2 | 1.1 | 1.4 | −2.0 | 4.0 | −1.9 |
| P15144 | ANPEP | Aminopeptidase N (AP-N) | −9.3 | −1.6 | −8.0 | −1.1 | 3.3 | −1.0 |
| P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 1.2 | 1.1 | 1.4 | −1.1 | 2.5 | −1.0 |
| P19971 | TYMP | Thymidine phosphorylase | 1.2 | 1.1 | 1.4 | −1.1 | 2.5 | 5.6 |
| P07195 | LDHB | L-lactate dehydrogenase B chain | 3.2 | 2.6 | 3.0 | 12.2 | −1.0 | 11.1 |
| P48735 | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial | −8.6 | −1.1 | 1.5 | 10.1 | −1.0 | 6.4 |
| P98160 | HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein | 4.2 | 6.2 | 1.4 | −3.8 | −3.5 | −3.5 |
| P07996 | THBS1 | Thrombospondin-1 | 1.2 | 12.2 | 1.4 | −15.6 | −1.7 | −14.2 |
a
Protein description, Gene name, UniProt acc, and molecular function annotated from UniProt (http://www.uniprot.org/)
b
Normalised spectral count ratio (Rsc) between datasets