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. 2015 Oct 13;6(35):38210–38224. doi: 10.18632/oncotarget.5690

Figure 6. E2F2, PTPRD, and connections to human breast cancer.

Figure 6

We examined a protein-protein interaction network and found that E2F2 and PTPRD were connected through MYC and STAT3 A. Unsupervised clustering of human breast tumor datasets and mouse tumor dataset revealed a cluster in which lung metastasis samples and human tumors were clustered B. Stratification of human Distant Metastasis Free Survival data by E2F2 pathway probability values showed differential effect of E2F2 loss in human tumors C. p-value < 0.0001).