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. 2015 Oct 12;6(35):38257–38269. doi: 10.18632/oncotarget.5499

Figure 2. Identifying candidate genes associated with grade progression.

Figure 2

A. Transcripts levels of 39 candidate genes were identified by microarray from the CGGA dataset (5 NBTs, 17 OIIs and 11OIIIs) which showed either gradual increases (33 genes) or decreases (6 genes) in the entire grade progression from NBT to OII and OIII (p < 0.05); The 39 candidate genes were obtained by overlapping data analysis from CGGA, GES16011 and REMBRANDT datasets. B. 16 candidate genes were further confirmed by the RNA-seq data of the CGGA dataset (27 OIIs and 11 OIIIs); C. The 16 candidate genes were validated on an independent RNA-seq data of the TCGA dataset (64 OIIs and 41 OIIIs).