Table 2. Final multivariable regression model for the identification of independent risk factors to develop RCC.
| Model | Variable | Coefficient β | Odds ratio (95% confidence interval) | P-value |
|---|---|---|---|---|
| Ulcerative colitis (all cases, n = 1061) | Male gender IBD related surgery Age at IBD diagnosis Montreal E3 colitisa |
1.169 1.499 0.023 0.598 |
3.218 (1.715–6.040) 4.477 (2.433–8.238) 1.023 (1.006–1.042) 1.818 (1.045–3.163) |
<0.001 <0.001 0.009 0.034 |
| Ulcerative colitis (sensitivity analysis, n = 1015) | Male gender IBD related surgery Age at IBD diagnosis Montreal E3 colitisa 5-ASA |
1.609 1.306 0.028 0.922 –1.746 |
4.999 (1.889–13.226) 3.692 (1.578–8.641) 1.029 (1.006–1.051) 2.513 (1.2005.262) 0.174 (0.044–0.687) |
0.001 0.003 0.011 0.015 0.013 |
| Crohn's disease (all cases, n = 845) | Age at IBD diagnosis Penetrating disease |
0.035 1.021 |
1.035 (1.014–1.057) 2.776 (1.320–5.836) |
0.001 0.007 |
| Crohn's disease (sensitivity analysis, n = 811) | Age at IBD diagnosis | 0.049 | 1.051 (1.028–1.074) | <0.001 |
Similar inclusion periods of IBD diagnosis (since 1991) for cases and controls were used in the sensitivity analysis (case control study A). IBD, inflammatory bowel disease; 5-ASA, 5-aminosalicylic acids.
a
Reference category is patients with Montreal E1 or E2 colitis